CA21154 - Translational control in Cancer European Network (TRANSLACORE)
TRANSLACORE
Understanding the importance of protein synthesis dysregulation in cancer
CA21154 - Translational control in Cancer European Network (TRANSLACORE)
Translacore
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CA21154 - Translational control in Cancer European Network (TRANSLACORE)
Map of TRANSLACORE Team Members Across Europe
Our aims
Philosophy
Understanding the importance of protein synthesis dysregulation in cancer
Objectives
Promoting multiple cross-disciplinary research partnerships
Capacity Building
Strengthen scientific interactions among experts across Europe with complementary skills
State of the art
Dysregulated translation in cancer exposes vulnerabilities that are amenable to targeted therapies.
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Translacore open database
Global & Regional Biobank Directories for Cancer Research
TRANSLACORE acts as a gateway to streamline access to translational cancer research resources across Europe and globally. This curated list of open-access biobank directories serves as a starting point for researchers to discover biospecimens, cohorts, and associated clinical data across multinational networks.
Cancer and Translation: How Cells Read Instructions, and What Happens in Cancer
Cancer and Translation: How Cells Read Instructions and What Happens in Cancer This illustrated brochure introduces the links between protein synthesis and cancer for a broad audience. Using the analogy of a recipe book and cellular cooks, it explains how DNA instructions are copied into mRNA and read by ribosomes to produce proteins. It explores how mutations and disrupted control of protein production can contribute to cancer, and introduces potential therapeutic approaches targeting protein synthesis, protein quality control and growth signalling. Developed within COST Action CA21154 TRANSLACORE, the brochure makes key molecular concepts accessible and highlights how collaborative European research can advance our understanding of cancer and inform future treatments.
Standard operating procedures for omics sample preparation
TRANSLACORE Working Group 2 has harmonized four standard operating procedures for preparing fresh-frozen tissues, blood and blood-derived specimens, bronchial lavage fluid, and patient-derived organoids for omics analyses. The protocols address sample handling, stabilization, processing, storage and quality assessment, with specimen-specific guidance for downstream applications. By promoting molecular integrity, traceability and consistent documentation of pre-analytical variables, these resources support reproducible research across laboratories and connect sample preparation with the analytical workflows described in Working Group 1 protocols.
