Dear TRANSLACORE participants,

We would like to invite you to the 17th Webinar organized by the Early Career Investigators network under the TRANSLACORE project and scheduled on February 26 at 13h30 PM CET online.

**Title : Harnessing epitranscriptomics to detect and manage pancreatic cancer**

**Abstract:** Pancreatic ductal adenocarcinoma (PDAC) remains the deadliest cancer, mainly due to late diagnosis and limited therapeutic options. The identification of early-detection biomarkers could therefore significantly improve patient outcomes. Recently, RNA modifications (epitranscriptomics) have emerged as an additional regulatory layer of gene expression in both healthy tissues and cancer, controlling the post-transcriptional fate of RNA in response to microenvironmental changes and cellular stress. Importantly, modified nucleosides released during RNA turnover can be detected in the bloodstream, and recent studies suggest that they may also bind cell-surface receptors and modulate immune and inflammatory signalling. Our team pioneered the use of multiplex analysis of RNA modifications for patient stratification. Building on this expertise, we hypothesize that profiling circulating modified nucleosides could both reflect early carcinogenic alterations and actively contribute to tumor development.


Kelly will present her recent work on identifying a circulating chemical signature for early PDAC detection and on the signaling roles of circulating nucleosides in immune activation

Introduction by:
- Dr. Paulina Podszywalow


Organising committee:

- Sophie Gomez
- Adolfo Rivero-Müller
- Paula Alepuz
- Nikolaos Balatsos
- Rafaela Lacerda Santos
- Paulina Podszywalow
- Gamze Guney Eskiler
- Cecilia Picazo
- Caroline Moyret Lalle


We would like to invite you to the 17th Webinar organized by the Early Career Investigators network under the TRANSLACORE project and scheduled on February 26 at 13h30 PM CET online. 

Kelly

17th Webinar for Early Career Investigators 

 COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. (www.cost.eu) | The TRANSLACORE Cost Action is bridging disciplines and expertise across Europe in order to advance an emerging field in cancer biology: translational control in cancer. It is providing a unique opportunity to understand this biological process leading to reconsider our view of gene expression control in this disease and deliver novel therapeutic opportunities.

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17th Webinar for Early Career Investigators